ࡱ> uwt Rtbjbj8[%77777KKK8O4K!(a c c c c c c $#2&: 7 774P!   j77a  a    ?'KI6 M f!0! l&l& l&7 4   !l& : 2010t^~W Of[fgWsSN @wWVKm^b/gvޘSU\ WV~pencNe_X YUOcknx0_0W[ُNpencۏLTy~f[Rg]b:Nxvzvt  2010t^~W Of[fgWs \VNSv'Yf[uir~f[|v Summer Institute in Statistical Genetics HYPERLINK "http://www.biostat.washington.edu/suminst/sisg/general"http://www.biostat.washington.edu/suminst/sisg/general -NvR^0RSNۏLvsQ zvc TewQSOc[vsQpencvRg0 2010t^~W Of[fgWsSN  -Nv z\N8g23-27e(WSN'Yf[>NR WsqQ gN*Nwg z k*N zc~$N)YJS wQSO zY N,{NR8g238g25e NHS,{N zyW OpencRgPopulation Genetic Data Analysis Kent Holsinger (Professor of Ecology and Evolutionary, Biology, University of Connecticut ) Bruce S. Weir (Professor and Chair of Biostatistics, University of Washington, Director, Summer Institute in Statistical Genetics),{N zWVh1RgGene Expression Profiling Gregory C. Gibson (Professor, School of Biology Georgia Institute of Technology)John Storey (Associate Professor, Lewis-Sigler Institute Department of Molecular Biology, Princeton University),{ N zpeϑW Of[Quantitative Genetics J. Bruce Walsh (Professor of Ecology and Evolutionary, Biology, University of Arizona)Dahlia M. Nielsen (Research Assistant Professor of Genetics North Carolina State University),{NR8g25 NHS8g27e,{V zN{|SOWV[MOsQT~elHuman Association Mapping Alison Motsinger-Reif (Assistant Professor of Statistics, North Carolina State University)Dahlia M. Nielsen (Research Assistant Professor of Genetics, North Carolina State University),{N zRiirSOWV[MOsQT~elPlant and Animal Association Mapping Bruce S. Weir (Professor and Chair of Biostatistics, University of Washington, Director, Summer Institute in Statistical Genetics)Michel Georges (Professor of Molecular Genetics, Universit de Lige),{mQ zpeϑ'`rWV[MOv~elQTL Mapping Rebecca W. Doerge (Professor of Statistics, Purdue University)Zhao-Bang Zeng (Reynolds Distinguished Professor of Statistics and Genetics, North Carolina State University),{N z(uR[W OpencۏLRgGenetic Data Analysis with R Thomas Lumley (Professor of Biostatistics, University of Washington)Kenneth M. Rice (Associate Professor of Biostatistics, University of Washington)8g238g25e NHS g N*N TeۏLv z8g25 NHS8g27e gV*N TeۏLv z0k*Nf[XTk*NekS bvQ-NN*N z0[ f[uvBlwQ gW Of[W@xTuir~f[W@x &^Kbc5uNMS Windows d\O|~:N[ Ws6e9f[uSZSXT6e9US N*N z6e91200CQ $N*N z6e91600CQvQNf[XT6e9US N*N z6e91600CQ $N*N z6e92000CQk- zf[XTNpe30-40N bn:Nbk0ߘ[[ccOHS OO[SeZft0Ws~~(W-NsQeV[NNROO?b f[XTSLN-NsQeVT|http://www.pkugv.com/index.asp T|ef/f 2010t^~W Of[fgWs vf[XT0bTe_\bThǏ5uP[N O~ _Xnl^HYPERLINK "mailto:xiangbozhang@pku.edu.cn"xiangbozhang@pku.edu.cnbT*bbkeg2010t^8g15eWs~Q[SSDe,{N zSOW OpencRg;NNKent Holsinger (Professor of Ecology and Evolutionary, Biology, University of Connecticut ) Bruce S. 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The course will cover the basics of quantitative genetics including: Fisher s variance decomposition, covariance between relatives, heritability, inbreeding and crossbreeding, and response to selection. Also an introduction to advanced topics such as: Mixed Models, BLUP, QTL mapping; correlated characters; and the multivariate response to selection. Background reading: Lynch, M., Walsh, B. (1998). Genetics and analysis of quantitative traits, Sinauer.,{V zN{|SOWV[MOvsQT~el;NNAlison Motsinger-Reif (Assistant Professor of Statistics, North Carolina State University)Dahlia M. Nielsen (Research Assistant Professor of Genetics North Carolina State University),g z\N~[N{|SOWV[MOvsQT~el0vSb)R(uޏNs^aۏLWV[MOvt; WV[MO[WNSOT[|vWVsQT[MO~elyceTޏ~R^'`r~RgelYtSO~gv~el; YKmՋYBgvW O!jWvRgel0Module 4: Human Association MappingInstructors: A. Motsinger-Reif, and D. NielsenThis module is an introduction to association mapping, focusing on human populations. Topics include: theory of linkage disequilibrium and mapping; basics of gene mapping study design; population and family-based association techniques for discrete and continuous traits; methods for detecting and accounting for population structure; and multiple testing issues. New data-mining methods for detecting complex genetics models are also discussed. ,{N zRiirSOWV[MOvsQT~el;NNBruce S. Weir (Professor and Chair of Biostatistics, University of Washington, Director, Summer Institute in Statistical Genetics)Michel Georges (Professor of Molecular Genetics, Universit de Lige),g z\N~[RiirSOWV[MOvsQT~el0vSbޏNs^aWV[MOvt [yceTޏ~'`rۏLSOT[|vsQTRgel hKmSO~g YPSOiirRg YKmՋ NSWVWvKm[el0cO(uw[pencv^T~oN[Ed\Ov~T0Module 5: Plant and Animal Association MappingInstructors: B. Weir and M. GeorgesThis module is an introduction to association mapping, focusing on plant and animal populations. 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